Saxagliptin CAS NO.361442-04-8

 Trading information  

Sample Service

Considering the various needs of buyers, we provide small quantity sample to customers. You are welcomed to contact us for the detailed specifications of our APIs and pharmaceutical intermediates. Customers are also expected to confirm the type of freight transport and  payment. Any more question please contact us directly.

Production of  Saxagliptin

The synthesis of Saxagliptin by Bristol-Myers Squibb by the amide coupling of N-Boc-3-hydroxyadamantylglycine (2) and methanoprolineamide (3) with EDC. The former is commercially available, whereas the latter is available as the N-Boc analog. The prolineamide moiety is subsequently dehydrated with trifluoroacetic anhydride to give the cyanide as the trifluoracetate ester, which is hydrolyzed. Removal of the Boc protecting group, followed by neutralization gives the desired product (1):

Research and Development

Relying on advanced research platform and relative service of China Medicine City, Allyrise have made achievements in areas of antineoplastic, antiviral, diabetes drugs in recent years, with more than 20 kinds of APIs and advanced intermediates magnified in pilotscale experiment. The products are widely sold to famous pharmaceutical companies from around the world. To enhance our research and development level, Allyrise developed close cooperation with foreign pharmaceutical companies in customer synthesis and developing new drugs.

Technical Team

Jiangsu Allyrise Pharmaceutical Co., Ltd have a young and innovative technician team with average age of 29 and backgrounds of famous universerties. We have rich experience in lab research and pilot scale experiment, laying the foundation for further personnel cultivation.